Table 3.
Infiltration of CD8+ T cells into the tumor microenvironment
| Cell type | Median baseline (cells/mm2) | Median day 22 (cells/mm2) | Median fold increase | Number of participants with fold increases (%) | Lower limit of 90% CI (% increasing) |
| CD8+ cells | 107.8 | 194.7 | 2.58 | 10* (83.3) | 61.4 |
| CD8+GzmB+ cells | 5.0 | 31.6 | 3.63 | 9* (75.0) | 52.5 |
| CD8+Tbet+ cells | 0.48 | 3.71 | 4.83 | 9* (75.0) | 52.5 |
| FoxP3+ cells | 11.63 | 13.75 | 1.15 | 8 (66.7) | 44.1 |
| Granzyme B+ cells | 9.11 | 37.6 | 2.93 | 8 (66.7) | 44.1 |
| Tbet+ cells | 1.34 | 7.45 | 4.02 | 9* (75.0) | 52.5 |
| CD20+ cells | 0.83 | 6.40 | 2.62 | 10* (83.3%) | 61.4 |
| CD8+Ki67+ cells | 59.5 | 104.6 | 2.07 | 10* (83.3%) | 61.4 |
| CD20+Ki67+ cells | 0.35 | 1.08 | 2.11 | 9* (75.0%) | 52.5 |
| CD83+ cells | 0.31 | 0.19 | 0.50† | 4 (33.3%) | 15.4 |
| Ki67+ cells | 980.0 | 1280.7 | 0.89 | 4 (33.3%) | 15.4 |
*Increased infiltration in 9/12 participants was designated as a promising result in the study design.
†Median fold increases calculated on 10 patients. Two were excluded for values of 0 at both baseline and Day 22.