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. 2022 Aug 23;62(17):4018–4031. doi: 10.1021/acs.jcim.1c01079

Table 3. Examples of the Qualitative Knowledge Extracted as Part of the Classification Scheme.

applicability domain species, end point extracted knowledge ref
substituted benzenes Tetrahymena pyriformis positive correlation with end point: Gupta et al. (2015)63
pIGC50 - MW,
- nAtomP,
- TopoPSA
negative correlation
- SHdsCH,
lipoaffinity index
pharmaceuticals D. magna, fish higher toxicity to D. magna: Kar et al. (2018)64
LC50 - keto group
  - aasC fragment
  higher toxicity to fish:
  - keto group,
  - X=C=X fragment,
  - R–C(=X)–X fragment,
  R–C≡X fragment