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. Author manuscript; available in PMC: 2022 Sep 14.
Published in final edited form as: J Alzheimers Dis. 2022;88(1):311–322. doi: 10.3233/JAD-220356

Figure 3: Interaction of IGF-1 or IGFBP-3 and CRP on MRI outcomes.

Figure 3:

Forest plots of cohort-specific and meta-analysis results for the interactions of (A) IGF-1 and dichotomized CRP on MRI measures and (B) IGFBP-3 and dichotomized CRP on MRI measures. CRP was dichotomized according to the 75th percentile (<75th percentile, ≥75th percentile).

Beta estimates and 95% confidence intervals (CI) are presented graphically in the center, where the square represents beta coefficients and the error bars the 95% confidence intervals per cohort according to the text on the right column. Meta-analysis results derived from random-effects (RE) models are presented with diamonds.

Models are adjusted for age, age-squared, sex, time between blood draw and MRI, waist-to-hip ratio, systolic blood pressure, hypertension treatment, diabetes mellitus, current smoking, and prevalent cardiovascular disease.

Abbreviations: FHS Gen 3: Framingham Heart Study Generation 3, SHIP-TREND: Study of Health in Pomerania TREND, IGF-1: insulin-like growth factor 1, IGFBP-3: insulin-like growth factor binding protein-3, GM: gray matter, WM: white matter, WMH: white matter hyperintensity, CRP: C-reactive protein