Table 2.
Heterogeneity measures for the associations between IGF-1 or IGFBP-3 and MRI outcomes
| Outcome | IGF-1 Heterogeneity | IGFBP-3 Heterogeneity | ||||
|---|---|---|---|---|---|---|
|
| ||||||
| Q | Q p-value | I^2 | Q | Q p-value | I^2 | |
|
| ||||||
| Total brain | 2.09 | 0.15 | 52.13 | 9.65 | <0.01 | 89.63 |
| CRP (Q1–3) | 2.08 | 0.15 | 51.91 | 6.58 | 0.01 | 84.80 |
| CRP (Q4) | 0.11 | 0.74 | 0.00 | 2.48 | 0.12 | 59.66 |
| Cortical GM | 0.07 | 0.79 | 0.00 | 1.46 | 0.23 | 31.48 |
| CRP (Q1–3) | 0.18 | 0.68 | 0.00 | 1.15 | 0.28 | 13.21 |
| CRP (Q4) | 0.14 | 0.70 | 0.00 | 0.09 | 0.77 | 0.00 |
| WM | 2.34 | 0.13 | 57.17 | 5.15 | 0.02 | 80.58 |
| CRP (Q1–3) | 1.35 | 0.25 | 25.82 | 3.15 | 0.08 | 68.29 |
| CRP (Q4) | 1.02 | 0.31 | 1.99 | 2.15 | 0.14 | 53.49 |
| WMH | 0.09 | 0.77 | 0.00 | 0.04 | 0.84 | 0.00 |
| CRP (Q1–3) | 0.10 | 0.76 | 0.00 | 0.77 | 0.38 | 0.00 |
| CRP (Q4) | 0.11 | 0.74 | 0.00 | 0.36 | 0.55 | 0.00 |
| Hippocampal | 0.02 | 0.89 | 0.00 | 0.05 | 0.83 | 0.00 |
| CRP (Q1–3) | 0.34 | 0.56 | 0.00 | 0.25 | 0.62 | 0.00 |
| CRP (Q4) | 0.02 | 0.90 | 0.00 | 1.83 | 0.18 | 45.24 |
Models are adjusted for age, age-squared, sex, time between blood draw and MRI, waist-to-hip ratio, systolic blood pressure, hypertension treatment, diabetes mellitus, current smoking, and prevalent cardiovascular disease. Fields in bold font show associations with high heterogeneity.
Abbreviations: IGF-1: insulin-like growth factor 1, IGFBP-3: insulin-like growth factor binding protein-3, Q: quartile; WMH: white matter hyperintensity.