Fig. 2.

Evolutionary genetics of CaP-associated variants. A Joint site frequency spectrum of risk allele frequencies in Europe and Africa (1KGP data). Minor allele frequencies are larger for Europe than Africa in the shaded region. Schumacher PRS variants are denoted by light blue points, Conti PRS variants are denoted by dark blue points, and PHS46+African PRS variants are denoted by green points. B Stacked strip charts reveal that PRS variants are not enriched for high iHS statistics in Great Britain or Nigeria when compared to the rest of the genome. One sample Kolmogorov-Smirnov goodness of fit tests were used to obtain p-values (null hypothesis: iHS percentiles are uniformly distributed). CPolyGraph results. For each PRS, p-values refer to tests of polygenic adaptation acting over the entire admixture graph. 1KGP population codes are described in the “Methods” section