Table 2.
Ability of PRS to distinguish between case and control status using the optimal set of variants for European and African datasets. Area under the curve (AUC) statistics and covariate-adjusted odds ratios (OR) are shown for each PRS. These odds ratios involve comparisons between individuals who have a PRS in the top decile to individuals who have a PRS in the middle 20%—i.e., they quantify the how well a risk score is able to distinguish between cases and controls for different parts of a PRS distribution after correcting for age and first 10 principal components
| PRS source | PRS ancestry | AUCUKBB (95% CI) | ORUKBB (95% CI) | AUCMADCaP (95% CI) | ORMADCaP (95% CI) |
|---|---|---|---|---|---|
| Schumacher | European | 0.675 (0.662–0.689) | 3.59 (2.89–4.49) | 0.538 (0.516–0.56) | 1.23 (0.91–1.67) |
| Conti | Multi-ancestry | 0.703 (0.694–0.713) | 5.29 (4.26–6.59) | 0.579 (0.558–0.601) | 1.86 (1.41–2.47) |
| Conti | European | 0.707 (0.698–0.717) | 5.71 (4.59–7.14) | 0.541 (0.519–0.563) | 1.60 (1.20–2.12) |
| Conti | African | 0.671 (0.662–0.681) | 4.00 (3.17–4.95) | 0.585 (0.563–0.607) | 2.01 (1.52–2.67) |
| Conti | Asian | 0.662 (0.652–0.672) | 3.32 (2.67–4.14) | 0.533 (0.511–0.555) | 1.83 (1.38–2.45) |
| Conti | Hispanic | 0.678 (0.668–0.688) | 3.93 (3.17–4.91) | 0.527 (0.505–0.549) | 1.65 (1.24–2.21) |
| PHS46 | European | 0.612 (0.598–0.627) | 2.37 (1.90–2.96) | 0.502 (0.48–0.524) | 0.95 (0.70–1.28) |
| PHS46+African | European + African | 0.608 (0.594–0.622) | 2.50 (2.00–3.15) | 0.547 (0.525–0.569) | 1.58 (1.20–2.11) |