Table 2.
Risk of incident MACEs for baseline remnant-C level
| Remnant-C | Events/n at risk | Unadjusted | Model 1 | Model 2 | Model 3 | ||||
|---|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | ||
| MACEs | |||||||||
| Tertile 1 | 552/3,448 | Ref | Ref | Ref | Ref | ||||
| Tertile 2 | 599/3,485 | 1.07 (0.96–1.21) | 0.228 | 1.11 (0.97–1.26) | 0.144 | 1.08 (0.94–1.23) | 0.285 | 1.11 (0.97–1.27) | 0.137 |
| Tertile 3 | 664/3,263 | 1.32 (1.18–1.47) | <0.001 | 1.36 (1.19–1.55) | <0.001 | 1.31 (1.14–1.50) | <0.001 | 1.38 (1.20–1.58) | <0.001 |
| Per 1 SD | 1.07 (1.04–1.12) | <0.001 | 1.08 (1.03–1.13) | <0.001 | 1.06 (1.01–1.11) | 0.010 | 1.07 (1.02–1.12) | 0.004 | |
| P for trend | <0.001 | <0.001 | <0.001 | <0.001 | |||||
| CVD death | |||||||||
| Tertile 1 | 192/3,448 | Ref | Ref | Ref | Ref | ||||
| Tertile 2 | 221/3,485 | 1.15 (0.95–1.40) | 0.152 | 1.21 (0.96–1.52) | 0.099 | 1.17 (0.93–1.47) | 0.192 | 1.20 (0.95–1.51) | 0.129 |
| Tertile 3 | 250/3,263 | 1.41 (1.17–1.70) | <0.001 | 1.51 (1.21–1.88) | <0.001 | 1.35 (1.08–1.70) | 0.009 | 1.38 (1.10–1.74) | 0.006 |
| Per 1 SD | 1.06 (0.99–1.13) | 0.081 | 1.07 (0.99–1.16) | 0.058 | 1.05 (0.97–1.14) | 0.249 | 1.05 (0.97–1.13) | 0.270 | |
| P for trend | <0.001 | <0.001 | 0.003 | 0.002 | |||||
| Nonfatal MI | |||||||||
| Tertile 1 | 267/3,448 | Ref | Ref | Ref | Ref | ||||
| Tertile 2 | 302/3,485 | 1.11 (0.92–1.34) | 0.181 | 1.09 (0.90–1.32) | 0.386 | 1.06 (0.88–1.29) | 0.534 | 1.10 (0.91–1.34) | 0.329 |
| Tertile 3 | 363/3,263 | 1.48 (1.26–173) | <0.001 | 1.38 (1.14–1.67) | 0.001 | 1.37 (1.13–1.65) | 0.001 | 1.53 (1.26–1.85) | <0.001 |
| Per 1 SD | 1.10 (1.06–1.16) | <0.001 | 1.10 (1.05–1.17) | <0.001 | 1.09 (1.03–1.16) | 0.004 | 1.10 (1.04–1.17) | <0.001 | |
| P for trend | <0.001 | <0.001 | <0.001 | <0.001 | |||||
| Nonfatal stroke | |||||||||
| Tertile 1 | 160/3,448 | Ref | Ref | Ref | Ref | ||||
| Tertile 2 | 160/3,485 | 0.99 (0.79–1.23) | 0.917 | 1.16 (0.90–1.49) | 0.240 | 1.13 (0.88–1.45) | 0.348 | 1.14 (0.88–1.47) | 0.311 |
| Tertile 3 | 165/3,263 | 1.12 (0.90–1.39) | 0.313 | 1.23 (0.96–1.59) | 0.105 | 1.18 (0.91–1.53) | 0.223 | 1.20 (0.92–1.57) | 0.177 |
| Per 1 SD | 1.05 (0.97–1.14) | 0.201 | 1.05 (0.96–1.15) | 0.304 | 1.03 (0.94–1.14) | 0.489 | 1.04 (0.95–1.14) | 0.414 | |
| P for trend | 0.318 | 0.091 | 0.200 | 0.138 | |||||
Model 1: Adjusted for sex, age, education, years of hypertension diagnosis, depression, smoking habit, alcohol consumption, systolic blood pressure, diastolic blood pressure, heart rate, BMI, and CVD history. Model 2: Adjusted for model 1 covariables plus levels of plasma glucose, eGFR, HbA1c, and LDL-C. Model 3: Adjusted for model 2 covariables plus treatment with biguanide, statins, and insulin.