Table 3.

Risk of incident MACEs for visit-to-visit variability of remnant-C level

Remnant-C	Unadjusted		Model 1		Model 2		Model 3
	HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value
MACEs
logSD	1.52 (1.31–1.76)	<0.001	1.45 (1.22–1.73)	<0.001	1.39 (1.16–1.65)	<0.001	1.41 (1.18–1.69)	<0.001
logARV	1.57 (1.35–1.82)	<0.001	1.49 (1.25–1.77)	<0.001	1.43 (1.20–1.71)	<0.001	1.45 (1.22–1.73)	<0.001
logCV	1.31 (1.02–1.69)	0.035	1.11 (0.84–1.49)	0.461	1.04 (0.78–1.39)	0.770	1.06 (0.79–1.41)	0.700
CVD death
logSD	1.31 (1.02–1.69)	0.037	1.39 (1.03–1.87)	0.029	1.28 (0.94–1.73)	0.111	1.27 (0.94–1.72)	0.120
logARV	1.42 (1.10–1.83)	0.007	1.57 (1.17–2.12)	0.003	1.47 (1.08–1.99)	0.013	1.46 (1.08–1.97)	0.014
logCV	1.03 (0.67–1.57)	0.901	1.03 (0.63–1.68)	0.910	0.93 (0.57–1.53)	0.786	0.92 (0.56–1.51)	0.743
Nonfatal MI
logSD	2.07 (1.69–2.52)	<0.001	1.91 (1.51–2.41)	<0.001	1.86 (1.46–2.36)	<0.001	1.92 (1.51–2.43)	<0.001
logARV	2.04 (1.67–2.50)	<0.001	1.90 (1.50–2.40)	<0.001	1.86 (1.47–2.36)	<0.001	1.90 (1.50–2.40)	<0.001
logCV	2.09 (1.48–2.95)	0.000	1.63 (1.10–2.43)	0.016	1.67 (1.05–2.33)	0.027	1.62 (1.09–2.42)	0.017
Nonfatal stroke
logSD	1.22 (0.92–1.62)	0.176	1.28 (0.92–1.78)	0.136	1.23 (0.88–1.72)	0.218	1.26 (0.90–1.76)	0.175
logARV	1.25 (0.94–1.67)	0.126	1.28 (0.92–1.78)	0.142	1.24 (0.89–1.73)	0.207	1.26 (0.90–1.76)	0.171
logCV	0.92 (0.57–1.48)	0.728	0.89 (0.52–1.52)	0.665	0.83 (0.48–1.43)	0.502	0.84 (0.49–1.45)	0.535

Model 1: Adjusted for sex, age, education, years of hypertension diagnosis, depression, smoking habit, alcohol consumption, systolic blood pressure, diastolic blood pressure, heart rate, BMI, and CVD history. Model 2: Adjusted for model 1 covariables plus levels of plasma glucose, eGFR, HbA_1c, and LDL-C. Model 3: Adjusted for model 2 covariables plus treatment with biguanide, statins, and insulin.