Table 1.
Effects on incremental changes in AUC during the 5 h interval after breakfast
| Parameter | Time interval | LS mean change from baseline (95% CI); P value | LS mean difference, sotagliflozin vs. empagliflozin (95% CI); P value | |
|---|---|---|---|---|
| Sotagliflozin | Empagliflozin | |||
| Glucose, h·mmol/L | 0–2 h | −2.0 (−2.6 to −1.3); <0.0001 | −1.0 (−1.6 to −0.3); 0.0036 | −1.0 (−1.9 to −0.1); 0.0283 |
| 0–3 h | −3.2 (−4.2 to −2.2); <0.0001 | −1.7 (−2.7 to −0.7); 0.0014 | −1.5 (−2.9 to −0.06); 0.0417 | |
| 0–5 h | −4.0 (−5.5 to −2.3); <0.0001 | −2.5 (−4.0 to −0.9); 0.0028 | −1.5 (−3.7 to 0.8); NS | |
| Insulin, h·pmol/L | 0–2 h | −205 (−277 to −132); <0.0001 | −115 (−187 to −42); 0.0029 | −90 (−194 to 13); NS |
| 0–3 h | −392 (−486 to −297); <0.0001 | −213 (−308 to −118); <0.0001 | −179 (−314 to −44); 0.0111 | |
| 0–5 h | −533 (−666 to −399); <0.0001 | −280 (−414 to −147); 0.0002 | −252 (−443 to −62); 0.0109 | |
| Proinsulin, h·pmol/L | 0–2 h | −4 (−6 to −2); 0.0003 | −1 (−3 to 1); NS | −3 (−5 to −0.01); 0.0495 |
| 0–3 h | −10 (−14 to −6); <0.0001 | −4 (−7 to −0.04); 0.0475 | −6 (−11 to −1); 0.0282 | |
| 0–5 h | −18 (−27 to −8); 0.0008 | −8 (−17 to 1); NS | −9 (−23 to 4); NS | |
| C-peptide, h·nmol/L | 0–2 h | −0.4 (−0.7 to −0.2); 0.0017 | −0.1 (−0.4 to 0.1); NS | −0.3 (−0.7 to 0.06); NS |
| 0–3 h | −1.0 (−1.3 to −0.6); <0.0001 | −0.3 (−0.6 to 0.1); NS | −0.7 (−1.2 to −0.2); 0.0120 | |
| 0–5 h | −1.5 (−2.1 to −0.9); <0.0001 | −0.5 (−1.1 to 0.1); NS | −1.0 (−1.9 to −0.2); 0.0220 | |
| aGLP-1, h·ng/L | 0–2 h | 7 (3–11); 0.0010 | −4 (−8 to 1); NS | 11 (5–17); 0.0007 |
| 0–3 h | 11 (6–17); 0.0002 | −4 (−10 to 1); NS | 16 (8–23); 0.0002 | |
| 0–5 h | 16 (9–23); <0.0001 | −6 (−13 to 1); NS | 22 (12–32); <0.0001 | |
| tGLP-1, h·ng/L | 0–2 h | 32 (16–47); 0.0002 | −8 (−24 to 7); NS | 40 (18–62); 0.0007 |
| 0–3 h | 52 (31–74); <0.0001 | −13 (−34 to 8); NS | 65 (35–96); 0.0001 | |
| 0–5 h | 87 (56–117); <0.0001 | −15 (−45 to 15); NS | 102 (59–145); <0.0001 | |
| PYY, h·ng/L | 0–2 h | 15 (−8 to 38); NS | −2 (−26 to 21); NS | 17 (−16 to 50); NS |
| 0–3 h | 44 (6–81); 0.0231 | 5 (−34 to 43); NS | 39 (−15 to 93); NS | |
| 0–5 h | 96 (30 to 163); 0.0057 | 33 (−35 to 102); NS | 63 (−32 to 158); NS | |
| GIP, h·ng/L | 0–2 h | −207 (−257 to −157); <0.0001 | −70 (−120 to −20); 0.0080 | −137 (−209 to −65); 0.0005 |
| 0–3 h | −278 (−350 to −206); <0.0001 | −102 (−174 to −29); 0.0073 | −176 (−280 to −73); 0.0015 | |
| 0–5 h | −336 (−444 to −229); <0.0001 | −173 (−280 to −65); 0.0025 | −164 (−317 to −11); 0.0368 | |
Boldface text highlights statistically significant differences. NS, not significant.