Table 4.
Associations of GDM diagnosed by the IADPSG and NICE criteria with adverse pregnancy outcomes in Asians,‖ whose OGTT remained blinded (n = 1,695)
| Adjusted | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Unadjusted | Model 1 | Model 2 | |||||||||||
| IADPSG | NICE | IADPSG | NICE | IADPSG | NICE | ||||||||
| OR (95% CI) | AIC | OR (95% CI) | AIC | OR (95% CI) | AIC | OR (95% CI) | AIC | OR (95% CI) | AIC | OR (95% CI) | AIC | ||
| Maternal adverse outcomes | |||||||||||||
| GH/PE | 1.60 (1.06–2.41)* | 1,079.2 | 1.12 (0.73–1.71) | 1,083.6 | 1.36 (0.88–2.10) | 1,029.7 | 1.04 (0.66–1.61) | 1,031.5 | 1.11 (0.70–1.76) | 1,003.6 | 0.99 (0.63–1.60) | 1,003.8 | |
| Primary CS | 1.26 (0.89–1.75) | 1,621.5 | 1.16 (0.84–1.60) | 1,622.3 | 1.28 (0.89–1.82) | 1,537.8 | 1.17 (0.83–1.63) | 1,538.8 | 1.06 (0.72–1.53) | 1,510.1 | 0.98 (0.69–1.39) | 1,510.2 | |
| Neonatal outcomes | |||||||||||||
| LGA | 1.80 (1.19–2.65)‡ | 1,059.3 | 1.77 (1.19–2.57)‡ | 1,059.2 | 1.70 (1.11–2.54)* | 1,060.4 | 1.63 (1.09–2.39)* | 1,060.8 | 1.56 (1.00–2.39)* | 1,026.1 | 1.71 (1.12–2.56)* | 1,023.9 | |
| Adiposity | 1.98 (1.29–2.96)‡ | 954.8 | 2.11 (1.41–3.11)§ | 951.4 | 2.13 (1.37–3.24)§ | 960.2 | 2.21 (1.47–3.30)§ | 957.5 | 1.87 (1.18–2.89)† | 952.1 | 2.15 (1.40–3.24)§ | 947.2 | |
| Clinical hypoglycemia | 1.54 (0.79–2.80) | 540.5 | 1.06 (0.52–1.98) | 542.2 | 1.70 (0.86–3.13) | 541.3 | 1.04 (0.50–1.98) | 543.6 | 1.73 (0.86–3.27) | 543.3 | 1.01 (0.48–1.96) | 545.6 | |
| Hyperinsulinemia | 2.89 (1.91–4.30)§ | 879.2 | 2.95 (1.98–4.34)§ | 876.1 | 2.78 (1.82–4.20)§ | 886.7 | 2.86 (1.90–4.26)§ | 883.5 | 2.37 (1.52–3.63)§ | 880.6 | 2.51 (1.65–3.78)§ | 876.9 | |
Model 1 was adjusted for maternal age, parity, ethnicity, and study center. Model 2 was adjusted for covariates in model 1 plus maternal height, BMI, and gestational age at OGTT, smoking status, alcohol use, maternal urinary tract infection (for GH/PE only), hospitalization before delivery, and mean arterial pressure at OGTT (except for GH/PE), family history of diabetes, and baby’s sex.
P < 0.05;
P < 0.01;
P < 0.005;
P < 0.001. ∥More than 92% of the Asians in the cohort were Chinese ethnicity.