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. 2022 Jul 26;45(9):2046–2054. doi: 10.2337/dc22-0579

Table 4.

Associations of GDM diagnosed by the IADPSG and NICE criteria with adverse pregnancy outcomes in Asians,‖ whose OGTT remained blinded (n = 1,695)

Adjusted
Unadjusted Model 1 Model 2
IADPSG NICE IADPSG NICE IADPSG NICE
OR (95% CI) AIC OR (95% CI) AIC OR (95% CI) AIC OR (95% CI) AIC OR (95% CI) AIC OR (95% CI) AIC
Maternal adverse outcomes
 GH/PE 1.60 (1.06–2.41)* 1,079.2 1.12 (0.73–1.71) 1,083.6 1.36 (0.88–2.10) 1,029.7 1.04 (0.66–1.61) 1,031.5 1.11 (0.70–1.76) 1,003.6 0.99 (0.63–1.60) 1,003.8
 Primary CS 1.26 (0.89–1.75) 1,621.5 1.16 (0.84–1.60) 1,622.3 1.28 (0.89–1.82) 1,537.8 1.17 (0.83–1.63) 1,538.8 1.06 (0.72–1.53) 1,510.1 0.98 (0.69–1.39) 1,510.2
Neonatal outcomes
 LGA 1.80 (1.19–2.65) 1,059.3 1.77 (1.19–2.57) 1,059.2 1.70 (1.11–2.54)* 1,060.4 1.63 (1.09–2.39)* 1,060.8 1.56 (1.00–2.39)* 1,026.1 1.71 (1.12–2.56)* 1,023.9
 Adiposity 1.98 (1.29–2.96) 954.8 2.11 (1.41–3.11)§ 951.4 2.13 (1.37–3.24)§ 960.2 2.21 (1.47–3.30)§ 957.5 1.87 (1.18–2.89) 952.1 2.15 (1.40–3.24)§ 947.2
 Clinical hypoglycemia 1.54 (0.79–2.80) 540.5 1.06 (0.52–1.98) 542.2 1.70 (0.86–3.13) 541.3 1.04 (0.50–1.98) 543.6 1.73 (0.86–3.27) 543.3 1.01 (0.48–1.96) 545.6
 Hyperinsulinemia 2.89 (1.91–4.30)§ 879.2 2.95 (1.98–4.34)§ 876.1 2.78 (1.82–4.20)§ 886.7 2.86 (1.90–4.26)§ 883.5 2.37 (1.52–3.63)§ 880.6 2.51 (1.65–3.78)§ 876.9

Model 1 was adjusted for maternal age, parity, ethnicity, and study center. Model 2 was adjusted for covariates in model 1 plus maternal height, BMI, and gestational age at OGTT, smoking status, alcohol use, maternal urinary tract infection (for GH/PE only), hospitalization before delivery, and mean arterial pressure at OGTT (except for GH/PE), family history of diabetes, and baby’s sex.

*

P < 0.05;

P < 0.01;

P < 0.005;

§

P < 0.001. ∥More than 92% of the Asians in the cohort were Chinese ethnicity.