FIG 7.

Serological responses following SARS-CoV-2 D614G, Delta, and Omicron inoculation in cats. Kinetics of antibody response against SARS-CoV-2 N protein. Serum from SARS-CoV-2 D614G (B.1), Delta (B.1.617.2), and Omicron BA.1.1 (B.1.1.529) inoculated cats collected at days 0, 7, and 14 pi were subjected to indirect ELISA analysis. y axis represents S/P ratio and different colors denotes different treatment groups. Samples were considered positive when cutoff value (S/P ratio) equal or above of 0.5. Data are presented as means ± standard error (A). Neutralizing antibodies (NAbs) responses to SARS-CoV-2 and cross-reactivity between D614G (B.1), Delta (B.1.617.2), and Omicron BA.1.1 (B.1.1.529) variants were assessed by PRNT90 (90% plaques reduction) (B) and VN (100% neutralization) (C). Data are presented as means ± standard deviation. * P < 0.05; ** P < 0.01; *** P < 0.005; **** P < 0.0001.