FIG 1.

Experimental scheme and mortality of suckling mice after SADS-CoV infection. (A) Sixteen female C57BL/6J mice were randomly divided into four groups and used to produce suckling mice. Two-, 5-, and 7-day-old suckling mice were infected with SADS-CoV, and 2-day-old mock-infected mice were used as the control group. Mice were observed for clinical signs and survival daily for 14 days, and three mice from each group were sacrificed to collect tissue samples at 1, 3, 5, 7, 10, and 14 dpi. (B) Survival rates of 2 (n = 8)-, 5 (n = 5)-, and 7-day-old (n = 8) infected and 2-day-old (n = 6) mock-infected C57BL/6J mice, and 2 (n = 7)-, 5 (n = 6)-, and 7-day-old (n = 7) infected and 2-day-old (n = 6) mock-infected BALB/c mice.