Table 4.

Gene set enrichment results.

Gene set	Number of genes in set	Enrichment score	Normalized enrichment score	Normalized $p$-value	FDR
Up-regulated
Myelin and white matter	33	0.65	2.06	$<0.001$*	$<0.001$*
Down-regulated
Neuronal health	17	$-0.46$	$-1.12$	0.46	0.68
Excitotoxicity	57	$-0.42$	$-1.23$	0.50	0.45
Inflammation and glia	27	$-0.36$	$-0.96$	0.52	0.89

Note: Results from Gene Set Enrichment Analysis (GSEA) using four gene sets (listed in Table S2). Enrichment score reflects degree to which a defined gene set is overrepresented at the top or the bottom of total ranked data set of transcripts. Normalized enrichment score accounts for differences in the size of gene set and can be used to compare across gene sets of interest.^78,79 Significantly enriched set is denoted by an asterisk. FDR, false discovery rate.