Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Aug 9;23(9):3822–3830. doi: 10.1021/acs.biomac.2c00671

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 The Authors. Published by American Chemical Society

Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Hit compounds do not increase hemoglobin oxygen binding affinity. Measurement of hemoglobin oxygen saturation in RBCs from 4 healthy donors (genotype HbAA). RBCs at 25% hematocrit were incubated with 500 μM voxelotor, chlormezanone, or gabazine or DMSO (control) for 1 h at 37 °C and then diluted to 1% hematocrit with drug. Voxelotor significantly decreased the P50 of the treated RBCs (p = 0.027). Chlormezanone and gabazine resulted in no significant (p > 0.05) change in P50 relative to control.