Table 1.

Summary of Findings for PICO Question 1^a

PPI compared to placebo for EoE
Outcomes and follow-up	No. of participants (studies)26–48	Certainty of the evidence (GRADE)	Relative effect, RR (95% CI)	Anticipated absolute effects
				Risk with placebo	Risk difference with PPI
Not achieving histologic remission (<15 eos/hpf); follow-up: mean 8 wk	1051 (23 observational studies)b	⊕◯◯◯ VERY LOWc,d	0.66 (0.61–0.72)e	867 per 1000	295 fewer per 1000 (338 fewer to 243 fewer)

^aThe risk in the intervention group (and its 95% CI) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).

^bIncluded 2 RCTs of PPI vs topical steroids.

^cI² = 81%; very inconsistent results in absolute terms.

^dPatients are different than for other interventions where PPI responders were excluded.

^eUsed historical control cohort of placebo arm of topical steroid studies.