Table 9.

Summary of Findings for PICO Question 6^a

Allergy-based elimination diets compared to placebo for management of EoE
Outcomes and follow-up	No. of participants (studies)57,64,66,68,69,74–81	Certainty of the evidence (GRADE)	Relative effect, RR (95% CI)	Anticipated absolute effects
				Risk with placebo	Risk difference with allergy-based elimination diets
Not achieving histologic response assessed with: <15 eos/hpf, follow-up: 8 wk	830 (11 observational studies)b,c,d,e,f	⊕◯◯◯ VERY LOWg	0.57 (0.33–0.73)	880 per 1000h	373 fewer per 1000 (581 fewer to 234 fewer)

^aThe risk in the intervention group (and its 95% CI) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).

^bSkin-prick test (SPT) + atopy patch test (APT), some had previously failed pharmacologic therapy (Licarous et al⁵⁷).

^cRemission defined as <10 eos/hpf (Quaglietta et al,⁷⁴ Rizo Pascual et al⁷⁵).

^dSPT + APT + PPT (Molina-Infante et al⁷⁶).

^eSPT + specific IgE testing (sIgE) + APT (Syrigou et al⁷⁹).

^fComponent-resolved diagnostics (Van Rhijn et al⁸⁰).

^gVery inconsistent results.

^hPlacebo group responses from topical steroid trials.