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. Author manuscript; available in PMC: 2023 Oct 1.
Published in final edited form as: Hypertension. 2022 Aug 22;79(10):2250–2261. doi: 10.1161/HYPERTENSIONAHA.122.19862

Figure 3. H2O2 production via NOX is necessary for S1P-induced dilation in microvessels from nonCAD subjects.

Figure 3.

A) Dilation elicited by S1P is significantly reduced in the presence of PEG-Catalase (500U, n=5), the non-specific NOX inhibitor apocynin (300μM, n=5) (B), the specific NOX2 inhibitor GSK2795039 (1μM, n=5) (C), and the NOX4 inhibitor GKT137831 (1μM, n=5) compared to S1P alone (n=12, ‡p<0.01, *p<0.05) (D).