FIGURE 6.

A011 inhibited the growth of MCF-7/ADR xenograft model in vivo. MCF-7/ADR cells were injected subcutaneously into the right flank of BALB/c-nu/nu nude mice. (A) Photographs of tumors. (B) Mean tumor weight was calculated for each group of tumors after dissection of nude mice. (C) Change in tumor volume over the 21 days treatment period. (D) Change in body weight of nude mice during the 21-days treatment period. Nude mice in Control group treated with saline. Nude mice in the A011 + ADR group were treated with A011 (1 mg/kg) in combination with ADR (adriamycin) (5 mg/kg), while the other groups were treated as depicted above. ADR: adriamycin. Data represent mean ± SD of three different experiments. *p < 0.05, **p < 0.01 vs. Control. #p < 0.05, ##p < 0.01 vs. ADR (5 mg/kg). A011 Induced Apoptosis and Downregulated ABCG2 Protein Expression in MCF-7/ADR Tumor Cells without Significant Toxicity to Liver and Kidney