Table 3. Results of meta-regression for blood NfL difference between MS and controls.

Covariate	Coefficient	SE	t	P
Age-matched
Mean age	-0.014	0.02	-0.65	0.488
Percent of female	-1.01	1.28	-0.79	0.430
Mean disease duration	-0.015	0.035	-0.43	0.670
Mean EDSS score	0.148	0.131	1.13	0.259
Sample size#	-0.0013	0.0032	-0.39	0.696
Not age-matched
Mean age	-0.041	0.018	-2.30	0.021
Percent of female	1.25	1.85	0.68	0.498
Mean disease duration	-0.033	0.02	-1.63	0.103
Mean EDSS score	-0.090	0.098	-0.92	0.358
Sample size	-0.0006	0.0007	-0.86	0.387

^# Excluding Manouchehrinia et al’s study that had a very large sample size.