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. 2022 Sep 14;8(37):eabq8276. doi: 10.1126/sciadv.abq8276

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Fig. 3. — (A) Sequence alignment of amino acid changes in lead immunogens relative to the native RBD sequence. Four recurring changes are highlighted in pink. (B) Crystal structure of lead 1 (slate) in complex with scFv C144 (gray). (C) Crystal structure of lead 3 (green) in complex with Fab P2B-2F6 (gray). (D) The crystal structures of lead immunogens 1 (slate) and 3 (green) are globally similar to WT RBD (gray; PDB:7BWJ) despite amino acid changes (recurring, spheres; unique, sticks). Insets illustrate key recurring substitutions (pink).