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. 2022 Sep 14;8(37):eabq2611. doi: 10.1126/sciadv.abq2611

Fig. 2. Inhibition of Chk2 promotes DRGN survival and neurite outgrowth in vitro.

Fig. 2.

(A) Western blot and (B) densitometry to show that Chk2i suppresses pChk2T68 and pChk2T383 in DRGN cultures. ***P = 0.00011, ANOVA with Dunnett’s post hoc test. (C) Representative images after treatment with Chk2i and quantification to show that Chk2i enhances (D) % surviving DRGN, (E) % DRGN with neurites, and (F) the mean neurite length. FGF2 was used as a positive control. ***P = 0.0001, ANOVA with Dunnett’s post hoc test. n = 3 wells per treatment, three independent repeats (total, n = 9 wells per treatment). Scale bars in (F) = 50 μm.