Fig 7. Summary of SAMD9 effect to DNA sensing pathway and proinflammatory responses.
Based on our finding, the lack of M062R during MYXV infection induces cGAS-dependent IFN-I production that is also regulated by SAMD9. The SAMD9 effect is at the upstream of the 2’3’-cGAMP production but does not significantly affect cGAS protein synthesis. Overall, SAMD9 plays a positive role in enhancing cGAS-dependent IFN-I induction and regulating the proinflammtory responses in our model system (the dotted line).