TABLE 3.
Preliminary analysis of correlations between sleep patterns and biomarkers
| Plasma TNF‐α | Plasma IL‐10 | Plasma ICAM‐1 | Plasma CRP | CSF TNF‐α | CSF IL‐10 | CSF ICAM‐1 | |
|---|---|---|---|---|---|---|---|
| Workday hours of sleep | 0.19 (0.14) | 0.26 (0.04) | 0.07 (0.57) | −0.05 (0.72) | 0.09 (0.51) | 0.01 (0.97) | −0.17 (0.21) |
| Weekend hours of sleep | −0.07 (0.57) | −0.07 (0.59) | 0.09 (0.47) | −0.16 (0.22) | 0 (0.99) | 0.02 (0.86) | −0.07 (0.59) |
| Average hours of sleep | 0.12 (0.34) | 0.18 (0.16) | 0.09 (0.5) | −0.09 (0.5) | 0.07 (0.61) | 0.01 (0.93) | −0.16 (0.24) |
| Average hours of sleep > = 7 hours | 0.15 (0.24) | 0.27 (0.03) | 0.15 (0.24) | −0.09 (0.49) | 0.06 (0.65) | −0.13 (0.35) | −0.04 (0.77) |
| Sleep quality rate (scale of 1‐5: 1, excellent; 5, poor) | −0.19 (0.13) | −0.16 (0.22) | −0.07 (0.61) | −0.07 (0.61) | −0.09 (0.5) | 0.02 (0.9) | 0.3 (0.03) |
| Adequate sleep | −0.17 (0.18) | −0.14 (0.28) | −0.17 (0.18) | −0.09 (0.47) | 0.07 (0.61) | 0.05 (0.69) | 0.24 (0.07) |
| Sleep adequacy | −0.07 (0.59) | −0.06 (0.64) | −0.04 (0.74) | −0.01 (0.95) | 0.01 (0.93) | 0.02 (0.9) | 0.12 (0.39) |
| Somnolence | 0.12 (0.34) | 0.11 (0.39) | 0.07 (0.58) | −0.12 (0.37) | −0.1 (0.45) | −0.06 (0.65) | −0.02 (0.91) |
| Sleep Problems Index | −0.13 (0.38) | −0.09 (0.56) | −0.15 (0.3) | ‐0.32 (0.03) | 0.02 (0.88) | 0.05 (0.74) | 0 (0.98) |
| Somnolence Problems Index | 0.06 (0.66) | −0.16 (0.23) | 0.04 (0.76) | −0.14 (0.31) | 0.14 (0.32) | −0.11 (0.44) | 0.1 (0.49) |
Note: Pairwise correlations (P‐value) between plasma or CSF inflammatory biomarkers and participant sleep patterns were calculated for all participants, after correction for sleep apnea, history of smoking, diabetes, high blood pressure, and high cholesterol. Sleep quality rates on a scale of 1–5: 1, excellent; 5, poor. Correlations reported are Spearman rank correlation coefficients. Bolded P‐values indicate significance. For all blood analytes, n = 70; for all CSF analytes, n = 63. For sleep characteristics, n as in Table 2.