Table 2.

Main types of TMB assays.

Type	Number of genes	Size (MB)	Germline analysis	TMB definition	Number of mutations detected for 10 m/MB in the genome	Cl 95% for a TMB evaluated at 10 m/MB	CV
WES	22 000	30	Yes	No. of somatic, missense mutations	306	Gold standard
MSK-IMPACT	468	1.5 MB	Yes	No. of somatic, missense mutations	14	[5.1; 15.7]	25
FoundationOne CDx	384	0.8	No	Synonymous and non-synonymous, short indel	8	[4.3; 19.7]	35
True Sight	500	2	No	Synonymous and non-synonymous, short indel	18	[5.3; 14.2]	22
Oncomine	409	1.7	No	Synonymous and non-synonymous, short indel	15	[4.9; 14.5]	24
QIAGEN Comprehensive Cancer Panel	160	0.7	No	Synonymous and non-synonymous, short indel	7	[4.0; 20.6]	37