TABLE 2.

STS in the Study Eye at Day 28 (Primary End Point)

	OC-01
	0.006 mg (n = 47)	0.03 mg (n = 48)	0.06 mg (n = 44)	Vehicle (n = 43)
Mean change from baseline (mm)
No.	47	46	40	43
Mean (SD)	10.0 (9.5)	11.8 (8.9)	11.4 (9.3)	3.2 (5.6)
Range (min to max)	−5 to 34	−2 to 29	−3 to 31	−4 to 26
Quartiles (25th, median, 75th)	3, 7, 15	5, 10, 15	5, 8, 19	0, 2, 5
LS mean change from baseline
LS mean (SE) [95% CI]	10.1 (1.2) [7.7–12.5]	11.4 (1.3) [8.9–13.9]	11.1 (1.3) [8.5–13.7]	3.7 (1.3) [1.1–6.2]
Treatment comparisons
LS mean difference (SE) [95% CI]*	6.4 (1.8)	7.7 (1.8) [3.8–11.7]	7.5 (1.9) [3.4–11.6]	—
P†		<0.001	<0.001	—

^*Dunnett-corrected 95% CIs.

^†ANCOVA P value was calculated using a model with baseline STS (study eye), baseline STS with a cotton swab nasal stimulation (study eye), and study sites as covariates.

max, maximum; min, minimum; SE, standard error.