Fig. 2.

Representative structures of the 42 most prevalent Fab-Fab interfaces. Domains are colored as follows: VH (light blue), CH1 (dark blue), VL (pink), CL (dark red). The labels for each interface include the cluster rank based on prevalence, interface name based on structurally central residue (Kabat numbering for Fv region, EU number for constant regions), nonredundant prevalence percentage, and mean buried surface area. Interfaces are ranked numerically based on prevalence, with equivalent prevalence being designated with arbitrary alphabetic qualifiers; for example, there are three interfaces that occur in 17 PDB entries for prevalence = 1.7 %, ranked as 9a, 9b, and 9c. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)