Table 1.
Mean value, standard deviation (SD), and coefficient of variance (CoV[%] = 100 × SD/mean) of adjusted and non-adjusted volume estimates of brain parenchyma (BP), bilateral thalamus (THAL), and bilateral hippocampus (HIPP) in the normal database. The last two columns give the Pearson correlation coefficients with TIV and age. Statistically significant (P < .0001) correlations are marked with an asterisk
| Residual method | ||||||
|---|---|---|---|---|---|---|
| ROI | Adjustment | Volume (ROIV) | Correlation with | |||
| Mean [ml] | SD [ml] | CoV [%] | TIV | age | ||
| BP (n = 4980) | No adjustment | 1112.66 | 117.28 | 10.54 | 0.79* | − 0.40* |
| After adjustment | 0.00 | 40.96 | 3.68 | 0.00 | − 0.00 | |
| THAL (n = 4988) | No adjustment | 14.97 | 1.67 | 11.17 | 0.52* | − 0.57* |
| After adjustment | 0.00 | 0.89 | 5.95 | 0.00 | 0.00 | |
| HIPP (n = 4955) | No adjustment | 7.16 | 0.81 | 11.26 | 0.42* | − 0.38* |
| After adjustment | 0.00 | 0.58 | 8.16 | − 0.00 | − 0.00 | |
| Proportion method | ||||||
| ROI | Adjustment | Proportion of TIV (ROIF) | Correlation with | |||
| Mean [%] | SD [%] | CoV [%] | TIV | Age | ||
| BP (n = 4995) | No adjustment | 81.3 | 5.45 | 6.70 | − 0.31* | − 0.76* |
| After adjustment | 0.00 | 3.28 | 4.04 | − 0.39* | − 0.00 | |
| THAL (n = 5007) | No adjustment | 1.10 | 0.11 | 10.41 | − 0.42* | − 0.70* |
| After adjustment | 0.00 | 0.08 | 7.14 | − 0.52* | 0.00 | |
| HIPP (n = 4986) | No adjustment | 0.52 | 0.06 | 11.41 | − 0.45* | − 0.45* |
| After adjustment | 0.00 | 0.05 | 9.65 | − 0.52* | − 0.00 | |