Table 2.
Frequency of the mtDNA variants in the ICU patients and population controls. All them were genotyped for the 7028 variant (C = haplogroup H). The 7028T were genotyped for the G4580A, A12308G, G13368A, G13708A, and C16223T variants to determine the common non-H haplogroups (see suppl. file methods).
|
≤65 years |
>65 years |
|||
|---|---|---|---|---|
| Covid-19 N = 148 |
Controls N = 182 |
Covid-19 N = 168 |
Controls N = 181 |
|
| 7028C | 57 (39 %) | 86 (47 %) | 88 (52 %) | 82 (45 %) |
| 7028T | 91 (61 %) | 96 (53 %) | 80 (48 %) | 99 (55 %) |
| p-value (T)OR (95 %CI) |
p = 0.11 OR = 1.43 (0.92–2.22) |
p = 0.19 OR = 0.75 (0.49–1-15) |
||
| 16223T | 22 (15 %) | 9 (5 %) | 12 (8 %) | 9 (5 %) |
| 16,223C | 126 (85 %) | 173 (95 %) | 156 (92 %) | 172 (95 %) |
| p-value (T) OR (95 %CI) | p = 0.002 OR = 3.36 (1.49–7.54) | p = 0.39 OR = 1.47 (0.60–3.59) | ||
| J | 18 (12 %) | 28(15 %) | 12 (7 %) | 17 (9 %) |
| K + U | 32 (22 %) | 47(26 %) | 30 (18 %) | 46 (25 %) |
| T | 6 (4 %) | 7 (4 %) | 17 (10 %) | 19 (10 %) |
| V | 3 (2 %) | 2 (1 %) | 4(2 %) | 6 (3 %) |
| IWX | 22 (15 %) | 9(5 %) | 12 (9 %) | 9 (6 %) |
| OTHER | 10 (6 %) | 3(2 %) | 5 (2 %) | 2 (2 %) |
patients ≤ 65 vs. > 65 years: C7028T, p = 0.01; C16223T, p = 0.03.