REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Anti-H3K4Me3	Abcam	ab8580; RRID:AB_306649
Anti-Influenza A	Abcam	ab128193; RRID:AB_11143769
Anti-Coronavirus	Millipore	MAB9013; RRID:AB_95425
Anti-mouse-Alexa 488	Invitrogen	A21202; PRID: AB_141607
Anti-NFAT-2	Santa Cruz	sc7294; RRID:AB_2152503
Anti-rabbit -Alexa 488	Cell Signaling	4412; RRID:AB_1904025
Anti-SARS CoV-2 Spike	GeneTex	GTX632604; RRID:AB_2864418
Anti-phospho-p38	Cell Signaling	4511S; RRID:AB_2139682
Anti-phospho-p65	Cell Signaling	3033S; RRID:AB_331284
Anti-GAPDH	Cell Signaling	97166; RRID:AB_2756824
Anti-phospho-ERK	Cell Signaling	4370; RRID:AB_2315112
Anti-hnRNPL	Santa Cruz	sc-32317; RRID:AB_627736
Anti-mouse-HRP	Invitrogen	A16011; RRID:AB_2534685
Anti-rabbit-HRP	Invitrogen	A16023; RRID:AB_2534697
Bacterial and virus strains
OC43 Coronavirus	ATCC	VR-1558
Influenza A (Texas/36/91)	Gift from Dr. Ronald Germain, NIAID	N/A
SARS CoV2 (D614G)	NIAID SARS Corona Virus Core Lab	N/A
SARS CoV2 (U.K)	NIAID SARS Corona Virus Core Lab	N/A
Chemicals, peptides, and recombinant proteins
LOPAC library	Sigma	200-664-3
Phorbol 12-myristate 13-acetate	Sigma	P8139
GM-CSF	R&D Systems	215-GM-050/CF
Hygromycin B	Thermofisher Scientific	10687010
LPS from Salmonella	Enzo Life Sciences	ALX-581-008-L002
DMSO	Sigma	D2650-100ML
Rutaecarpine	Sigma	R3277-5MG
Syk inhibitor IV	Sigma	574714-2MG
β-glucan	David Williams	East Tennessee State University
TaqMan™ Gene Expression Master Mix	Thermofisher Scientific	4369016
Paraformaldehyde (Formaldehyde) Aqueous Solutio	Electron Microscopy Sciences	15714-S
Protease Inhibitor Cocktail powder	Sigma	P2714-1BTL
Pierce™ Protein A/G Agarose	Thermofisher Scientific	20421
Proteinase K Solution	Thermofisher Scientific	25530049
UltraPure™ Phenol:Chloroform:Isoamyl Alcohol	Thermofisher Scientific	15593031
Critical commercial assays
West Dura Extended Duration Substrate reagents	Thermofisher Scientific	34076
Luciferase Assay System	Promega	E1500
Dual-Luciferase® Reporter Assay System	Promega	E1960
CellTiter-Glo® Luminescent Cell Viability Assay	Promega	G7570
RNeasy Plus Mini Kit	Qiagen	74134
iScript™ Reverse Transcription Supermix for RT-qPCR	Bio-rad	1708841
Human TNF ELISA Set	BD Biosciences	555212
Human IL-6 ELISA Set	BD Biosciences	555220
Human IL-12/IL-23p40 Flex	BD Biosciences	560154
NE-PER™ Nuclear and Cytoplasmic Extraction Reagents	Thermofisher Scientific	78833
Deposited data
RNA Sequencing Data	GEO	GSE210476
Experimental models: Cell lines
THP1 monocytes	ATCC	TIB-202
U937 monocytes	ATCC	CRL-1593.2
THP1 B5 reporter cells	Home	(Li et al., 2015)
Primary monocytes	NIH blood bank	NIH
A549-hACE2	Dr. Jonathan Yewdell,	NIAID, NIH
Oligonucleotides
TNF Promoter forward primer-ChIP qPCR	IDTDNA	ACACACAAATCAGTCAGTGG
TNF Promoter reverse primer-ChIP qPCR	IDTDNA	CTTCTGTCTCGGTTTCTTCTC
IL6 Promoter forward primer- ChIP qPCR	IDTDNA	GGAGCAGTGGCTTCGTTTCA
IL6 Promoter reverse primer- ChIP qPCR	IDTDNA	CGGTGGGATTCTTTGGTGTG
IL1B Promoter forward primer-ChIP qPCR	IDTDNA	AAAGAAGTGAATGAAGAAAAGT
IL1B Promoter reverse primer-ChIP qPCR	IDTDNA	AGTTGATGTCCACATTAAAATA
IL6 reverse-qPCR	IDTDNA	GCAACTGGACCGAAGGC
IL6 forward-qPCR	IDTDNA	AAGCTCTATCTCCCCTCCAGGA
IL6 PROBE	IDTDNA	56-FAMCTTCTCCAC/ZEN/ AAGGGCCT
HPRT forward-qPCR	IDTDNA	CTGGAAAGAATGTCTTGA TTGTGG
HPRT reverse-qPCR	IDTDNA	CTTGCGACCTTGACCATCTT
HPRT probe-qPCR	IDTDNA	56-FAM/AGACTTTGCTT/ZEN/ TCCTTGGTCAGGCA
TNF forward-qPCR	IDTDNA	CCAGGGACCTCTCTCTAATCA
TNF reverse-qPCR	IDTDNA	TCAGCTTGAGGGTTTGCTAC
TNF PROBE	IDTDNA	56-FAM/AGTGACAAG/ZEN/ CCTGTAGCCCA
IFNB1 forward- qPCR	IDTDNA	TGAGCAGTCTGCACCTGAA
IFNB1 reverse-qPCR	IDTDNA	ACAGTGACTGTACTCCTTGG
Human IFNB1 PROBE	IDTDNA	56-FAM/ATTCTGCAT/ZEN/ TACCTGAAG
Software and algorithms
Graphpad Prism v9	GraphPad	https://www.graphpad.com
Bioconductor tool	Bioconductor.org	https://bioconductor.org/packages/release/bioc/html/EnhancedVolcano.html