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. 2022 Sep 15;40(42):6114–6124. doi: 10.1016/j.vaccine.2022.08.024

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© 2022 Published by Elsevier Ltd.

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Fig. 2 — Antibodies against irrelevant lipid nanoparticles (LNPs) and polyethylene glycol (PEG) in vaccinees’ sera. Sera from BNT162b2 (left column) or mRNA-1273 (right column) vaccinees collected at baseline (n = 10 for BNT162b2 and n = 10 for mRNA-1273 groups), 18.9 days (arithmetic mean ± 2.4 SD) after the prime (n = 10 for BNT162b2 and n = 10 for mRNA-1273 groups) and 19.3 days (arithmetic mean ± 3.9 SD) after the boost (n = 10 for BNT162b2 and n = 10 for mRNA-1273 groups), were tested for IgG antibodies against irrelevant LNPs (A and B), PEGylated BSA 20 kDa (C and D), 3.35 kDa PEG (E and F) by ELISA. Dotted line represents the limit of detection (LOD) of the assay. Statistically significant differences between post-prime/post-boost vs baseline antibody levels are shown. One-way ANOVA with Tukey’s multiple comparisons test was used to determine statistical significance. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001.