Table 2.

Univariate and multivariate analysis of factors associated with overall survival

Variables	Univariate analysis			Multivariate analysis
	HR	95% CI	p value	HR	95% CI	p value
Age ≤ 60 years	1.193	0.691, 2.060	0.527
Male	0.541	0.229, 1.281	0.163
Single tumour	0.667	0.357, 1.246	0.204
PVTT degree (I+II)	0.624	0.379, 1.025	0.063	0.536	0.338, 0.852	0.008*
Hepatitis B	0.463	0.153, 1.399	0.172
AFP ≤ 400 ng/ml	0.559	0.319, 0.982	0.043	0.575	0.350, 0.947	0.003*
Variceal bleeding	1.075	0.553, 2.088	0.832
Child-Pugh class A	0.658	0.314, 1.377	0.267	0.588	0.350, 0.990	0.046*
BCLC C stage	0.632	0.249, 1.606	0.632
MELD score ≤ 11	1.609	0.754, 3.435	0.219	1.778	0.912, 3.468	0.091
Treatment group B	5.994	3.222, 11.153	< 0.001	5.799	3.177, 10.585	< 0.001*

Notes: Treatment group B, patients without TIPS plus sequential systemic therapy, only symptomatic and supportive treatment; ^* p value ≤ 0.05 was considered to indicate statistical significance

Abbreviations: HR hazard ratios, CI confidence interval, PVTT portal vein tumour thrombus, AFP alpha-fetoprotein, BCLC Barcelona Clinic Liver Cancer, MELD Model for End-Stage Liver Disease