Table 1.

Results. Percentage of volume loss per year for all brain regions and results of correlation with patient age and clinical scores (with covariate sex)

Region of interest	Volume change (per year)			Correlation (r-values)
	%	Standard deviation		With age	With Hamburg jNCL Total score
		Upper limit	Lower limit
Supratentorial cortical GM	− 4.60	− 4.40	− 4.78	0.862*	0.850*
Female supratentorial cortical GM Male supratentorial cortical GM	− 4.68  − 4.47	− 4.46  − 4.12	− 4.90  − 4.83	0.932* 0.768*	0.887* 0.801*
Supratentorial WM	− 0.97	− 0.74	− 1.21	0.561*	0.563*
Cerebellar cortex	− 3.95	− 3.61	− 4.28	0.692*	0.750*
Basal ganglia/thalamus	− 3.87	− 3.55	− 4.20	0.691*	0.805*
Hippocampus	− 3.83	− 3.60	− 4.07	0.802*	0.787*
Lateral Ventricles	+ 12.06	+ 13.13	+ 11.02	0.683*	0.606*

^*All p-values < 0.00001, except supratentorial WM: p-values: with age = 0.0001, with clinical score = 0.00012