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. 2022 Sep 14;13:5401. doi: 10.1038/s41467-022-33143-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a FLT3 expression across different B-ALL subtypes in the US cohort of 1988 children and adults (Cohort 1), with the highest expression of FLT3 in ZNF384-r (ZNF384-rearrangement) ALL (n = 1988). b FLT3 expression in ALL cases (n = 49) with various ZNF384 fusions in cohort 1. Subgroups were defined by fusion partners of ZNF384. Other: fusion partners include ARID1B, CLTC, CREBBP, EWSR1, NIPBL, and SMARCA2. c FLT3 expression across different B-ALL subtypes in cohort 2 (n = 377), with the highest expression of FLT3 in ZNF384-r ALL. d FLT3 expression across ZNF384 fusions (n = 17) in the Asian cohort (Cohort 2). Subgroups were defined by fusion partners of ZNF384. Other: fusion partners include USP25 and CREBBP. e FLT3 mutations in ZNF383-r ALL from each ALL cohort. A.U. arbitrary units. Center lines indicate median values of FLT3 expression. Source data are provided as a Source Data file.