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. 2022 Sep 14;8:40. doi: 10.1038/s41526-022-00225-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A Stacked bar graphs showing the expression (in TPM) of the ten most abundant detected genes in individual plasma and whole blood samples. Pink bars on the bottom represent abundance of all other genes detected. B Scatterplot of all genes detected in pre- and post- treatment whole blood samples. Genes that are significantly up-regulated (p-adj. (Benjamini-Hochberg) < 0.05) in post-treatment samples are shown in red, genes that are significantly down-regulated (p-adj. (Benjamini-Hochberg < 0.05) in post-treatment samples are shown in blue. C Scatterplot of all genes detected in pre- and post- treatment plasma samples. Genes that are significantly up-regulated (p-adj. (Benjamini-Hochberg) < 0.05) in post-treatment samples are shown in red, genes that are significantly down-regulated (p-adj. (Benjamini-Hochberg < 0.05) in post-treatment samples are shown in blue. D Heatmap showing differential expression of significantly differentially expressed genes (p-adj. (Benjamini-Hochberg) < 0.05) between pre-treatment (teal) and post-treatment (salmon) plasma samples of three high-ICP patients. E Gene set enrichment analysis of gene expression in pre- vs. post-treatment high-ICP plasma patient samples (p-adj. (Benjamini-Hochberg) < 0.05).