Fig. 2.

Dataflow for computing pathway activation. Based on patient imaging and brain atlases, Lead-DBS (orange box) reconstructs the electrode and provides a description of tissue and water diffusion distributions in the brain. These data are used by OSS-DBS (green box) to create an accurate patient-specific volume conductor model. The model is then employed to compute electric potential distribution in space and time along axon models allocated on trajectories described by a pathway atlas. Finally, for the given distribution, the cable equation is solved to probe axonal activation, i.e. occurrence of an action potential in response to DBS.