Fig. 5.

Theoretical 100% UPDRS-III improvement optimal profile. MC and PMC refer to the primary and premotor cortical regions, SMA – supplementary motor area; cf and hdp are the corticofugal and the hyperdirect pathways, respectively; Ansa – ansa lenticularis, Lent – lenticular fasciculus, CbTh – cerebellothalamic pathway; l, f, up - lower extremity, face-neck region, and upper extremity in the primary motor cortex. A: percent activation for the optimal profile and the best responders from each cohort (should not be confused with the three patients that had the highest normalized interprotocol improvement). Note that the match between these datapoints and the optimal profile occurs for different pathways, suggesting that two distinct DBS mechanisms might be present. The mean values of optimized weighting factors below the bars can be interpreted as the importance of matching the optimal profile for a particular pathway. Red boxes highlight pathways with the highest effect on the correlation model. B: box plots of the optimized weighting factors computed with the ’leave-one-out’ approach. Note the low number of outliers.