Fig. 6.

Correlation of UPDRS-III improvement with weighted and unweighted Canberra distances to the optimal profile ${\mathcal{A}}_{\mathrm{optimal}}$. The profile was defined in the pathway activation space based on three patients with the highest normalized interprotocol UPDRS-III improvement. The weighting of pathway contributions to the Canberra distances is determined using the rest of the training cohort. A: significant inverse correlations are observed in the training cohort whether with or without the weighting (the three patients used for derivation of ${\mathcal{A}}_{\mathrm{optimal}}$ are excluded). Dash lines between datapoints depict the interprotocol binary correlation (black – valid prediction, purple – false), the best responders from Fig. 5 are marked with red circles. B: in the held-out test cohort, only the weighted metric has a statistically significant correlation with UPDRS-III improvement.