Fig. 7.

Pathway activation visualized in Lead-DBS. A: pathways whose activation levels determine the UPDRS-III improvement (shown in MNI space). Cyan and blue – the hyperdirect pathway, descending from the face-neck and upper extremity of the primary motor cortex, red – the corticofugal pathway, descending from the supplementary motor area, green – lenticular fasciculus, orange – ansa lenticularis. B and C: pathway activation (shown on computational axon models in patient-specific space) for the best responders in the training and the test cohorts, respectively. Axons closer than 0.1 mm to the electrode are excluded (purple) due to presumable glial scaring and neurodegeneration. Note the high recruitment of the hyperdirect and the corticofugal pathway for the best responder in the test cohort.