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. Author manuscript; available in PMC: 2023 Sep 13.
Published in final edited form as: Immunity. 2022 Jul 15:S1074-7613(22)00294-1. doi: 10.1016/j.immuni.2022.06.021

Figure 6. RNA-seq analysis of WT, Mrgpra2 dKO and Def cKO skin 24 hours post-S. aureus infection.

Figure 6.

(A) Volcano plots illustrating genes with significantly down- (blue) or up-regulated (red) expression in the Mrgpra2 dKO (left) or Def cKO (right) infected skin compared to WT. Boxed areas in the upper-left corners were magnified to show the most significantly down-regulated genes in detail.

(B) FPKMs of key pro-inflammatory genes in WT, Mrgpra2 dKO and Def cKO naïve and S. aureus-infected skin. n=6

(C) Top altered Ingenuity gene ontology pathways in Mrgpra2 dKO (top) and Def cKO (bottom) S. aureus infected skin.

(D) Heat maps depicting FPKM of neutrophil-associated genes and genes related to granulocyte adhesion and diapedesis.

Results are presented as mean ± SEM from one experiment. ***p < 0.001, ****p < 0.0001, *****p < 0.00001, n.s. not significant by one-way ANOVA.

See also Figure S6.