Table 4.

A comparison of geometric features of the cerebral vascular tree of healthy subjects and AD patients.

	Healthy subjects	AD patients (CDR = 0.5, 1)	AD patients (CDR = 2)	p - value
Total length (m)	3.92 ± 0.90	4.41 ± 1.41	5.21 ± 1.86	0.011*
Number of branches	238 ± 118	283 ± 126	369 ± 145	0.079
Average diameter (mm)	2.23 ± 0.34	1.98 ± 0.31	1.74 ± 0.29	0.022*
Fractal dimension	1.78 ± 0.24	1.86 ± 0.19	1.91 ± 0.25	0.016*
Tortuosity (rad/cm)	6.74 ± 2.96	8.03 ± 3.11	10.27 ± 3.48	0.027*

All the data represent mean±standard deviation with varying clinical dementia rating (CDR) unless otherwise indicated. The p-values were corrected by the Benjamini-Hochberg method to control for the false detection rate. The significantly different features (p<0.05) are highlighted with a *. rad: radians