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. 2022 Sep 14;7:49. doi: 10.1038/s41536-022-00239-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a human SCs exhibited a spindle-shaped and bipolar or occasionally multipolar cell morphology. As the concentration of PRP was increased, the proliferation of human SCs increased. (scale bar, 100 μm). b The number of human SCs were increased significantly and dose-dependently by PRP. After treatment for 96 hours, 10% PRP increased SC cell count significantly more than in non-treated controls. (#, compared between 0% and 5%, #P < 0.05; *compared between 0% and 10%, *P < 0.05, **P < 0.005, **P < 0.0001). c Representative light photomicrographs of migrated human SCs induced by 0%, 5%, and 10% PRP after incubation for 4 or 8 h by the transwell assay (scale bar, 100 μm). d Human SCs treated with 5% PRP for 8 h had significantly greater proliferation rates than non-treated controls (*P < 0.05) The number of migrated cells in 10% PRP is higher than in both non-treated cells and 5% PRP treated cells. (**P < 0.0001, respectively). e PRP significantly and dose-dependently increased SCs migration rate as compared with non-treated SCs. f The migration rate of cells treated with 10% PRP was 4.25-fold greater than that of non-treated controls (P < 0.05). SCs Schwann cells, PRP platelet-rich plasma.