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. 2022 Sep 14;7:49. doi: 10.1038/s41536-022-00239-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Schematic illustration of nerve. An axon surrounded by a myelin sheath and Schwann cells, which are located in myelin and release neurotrophic factors. b Western blot analysis of neural regeneration-related proteins in human SCs which were treated with different concentrations of PRP. All blots derive from the same experiment and were processed in parallel. c, d Quantification of neurotrophic factors including NT3 and NGF. As the concentration of PRP increased the expressions of neurotrophic factors increased more so than that observed in non-treated controls. e, f MAG expression was increased dose-dependently by PRP. ERK (a MAG-related axon cytoskeletal protein) expression was also increased by PRP. g Schematic illustration of connection between axon and myelin. h The expression of NGF in human SCs by ELISA; human SCs were observed to express NGF in a PRP dose-dependent manner. SC Schwann cell, PRP platelet-rich plasma, NGF nerve growth factor, NT-3 neurotrophin-3, MAG myelin-associated glycoprotein, MBP myelin basic protein, ERK extracellular signal-regulated kinase protein.