TABLE 1.

Functions of m⁶A modification-related proteins.

Type	Genetic name	Function	References
m 6 A writer	METTL3	Identify the conservative base sequence of m6A, catalytic methylation modification	Geula et al. (2015)
	METTL14	Assist METTL3 to catalytic methylation modifications	Wang et al. (2016)
	WTAP	Promote METTL3 and METTL14 heterogeneous dilate	Agarwala et al. (2012)
	VIRMA	Special modification of the 3′UTR region	Yue et al. (2018)
	RBM15	Combined with the m6A complex and recruit it to a special RNA site	Patil et al. (2016)
	ZC3H13	Connect to WTAP to mRNA binding factor Nito	Wen et al. (2018)
	METTL16	Catalytic methylation modification	Pendleton et al. (2017)
m 6 A eraser	FTO	Delete methylation modification	Jia et al. (2011)
	ALKBH5	Delete methylation modification	Zheng et al. (2013)
m 6 A reader	YTHDC1	Recruit splicing factors to splicing target mRNAs, promoting mRNA output degradation and specific transcription	(Xiao et al., 2016; Roundtree et al., 2017; Shima et al., 2017)
	YTHDC2	Adjust the stability and translation of mRNA	Hsu et al. (2017)
	YTHDF1	Recruit translation start factor to promote the translation of mRNA	Wang et al. (2015)
	YTHDF2	Combined with m6A modifiers to recruit CCR4-NOT deadenylase complex acceleration destination mRNA degradation	Du et al. (2016)
	YTHDF3	Promote mRNA degradation or medium translation	(Li et al., 2017a; Shi et al., 2017)
	HNRNPA2B1	Promote primary microRNA processing	Wu et al. (2018)
	HNRNPC/G	Mediate mRNA splicing	(Liu et al., 2015; Wang et al., 2015)
	IGF2BP1/2/3	Improve the stability of mRNA	Huang et al. (2018)
	eIF3	Combined with m6A to start translation	Meyer et al. (2015)
	FMRP	Adjust the stability, translation and nuclear output of mRNA	Santoro et al. (2012)
	Prrc2A	Improve the stability of mRNA	Wu et al. (2019)