TABLE 2.

Functions of m⁶A modification-related proteins in neurological diseases.

Disease type	m6A regulator	Function	References
Alzheimer’s disease	METTL3	Involve in the pathogenesis of AD	Zhao et al. (2021)
	FTO	regulate the mTOR signaling pathway and affected the development of AD	Li et al. (2018b)
	HNRNPA2B1	Involved in the regulation of AD	Kolisnyk et al. (2016)
Parkinson’s Disease	METTL14	Affect the production of key enzymes required for dopamine synthesis	Teng et al. (2021)
	FTO	Maintain dopaminergic neuron function	(Hess et al., 2013; Qi et al., 2022)
	HNRNPC	regulate dopaminergic proliferation	Quan et al. (2021)
	ALKBH5	Relate to the risk of PD	Qiu et al. (2020)
Major depressive disorder	FTO	Target ADRB2 induces depression-like behaviors	Liu et al. (2021a)
	FTO	Target the CaMKII/CREB signaling pathway modulates hippocampal synaptic plasticity	Shen et al. (2021)
	FTO	Affect resistance to tricyclic antidepressants	Wu et al. (2021)
	FTO	regulate the function of astrocytes	Huang et al. (2020b)
Stroke	METTL3	Involve in the formation of early stress granule cells	Si et al. (2020)
	YTHDF1	Involve in inflammatory response in stroke model mice	Zheng et al. (2020)
	YTHDC1	Influence the degradation of PTEN mRNA	Zhang et al. (2020)
Glioblastoma	METTL3	Influence self-renewal capacity of GBM cells	Li et al. (2019)
	METTL3	Influence the development process of GBM	Cui et al. (2017)
	METTL3	Influence tumor growth and development	Visvanathan et al. (2018)
	METTL3	Maintain specific gene expression in GSCs and regulate oncogenic-related signaling pathways	Visvanathan et al. (2019)
	METTL3	Regulates DNA repair factors and affects cellular drug resistance	Shi et al. (2021a)
	WTAP	Involve in carcinogenesis	Jin et al. (2012)
	FTO	Affect GBM cell proliferation, migration and invasion	Zhang et al. (2022)
	ALKBH5	Influence the GSCs self-renewal and tumorigenesis	Zhang et al. (2017)
	ALKBH5	Influence the radioresistance and invasive ability of GSCs	Kowalski-Chauvel et al. (2020)
	YTHDF2	Influence the development process of GBM	Dixit et al. (2021)
	YTHDF2	Influence the GBM cell proliferation, invasion, and tumorigenesis	Fang et al. (2021)
	YTHDF2	Involve in UBXN1 mRNA degradation	Chai et al. (2021)
	IGFBP1/2/3	Affects the formation of GBM microenvironment, regulates carcinogenic factors, affects GBM aerobic glycolysis, and affects GBM prognosis	(Liu et al., 2021b; Sun et al., 2021; Xiong et al., 2022)