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. 2022 Sep 14;8:92. doi: 10.1038/s41421-022-00434-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a UMAP plot exhibiting the identified clusters of the STRT and 10× datasets. b UMAP plot exhibiting the cell tissue sources of the STRT and 10× datasets. c Dot plots presenting the normalized expression level of corresponding markers of each cell cluster in the STRT dataset. d Heatmap showing the average normalized GRN expression scores. e UMAP plot exhibiting the identified clusters of normal epithelial cells in the STRT and 10× datasets. f The upper panel exhibiting large-scale CNVs of single cells inferred based on normal epithelial cells in the STRT dataset. The middle panel exhibiting large-scale CNVs of single cells inferred based on epithelial cells from tumor tissues in the STRT dataset. The lower panel exhibiting the CNV called from the WES data of P3–P6. g Histogram showing the cell composition percentage of each sample inferred by the deconvolution analysis. h Representative IHC staining of TAGLN in adjacent normal and primary tumor tissues (original magnification 100×). The rows of the paired normal and tumor samples are from the same patients, and three individual patients are listed. Scale bar, 100 μm.