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. 2022 Sep 14;8:92. doi: 10.1038/s41421-022-00434-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Heatmap showing the Pearson correlation clustering of identified intra-tumor expression programs. b Heatmap showing the Pearson correlation clustering across gene signatures extracted from the PCA output. c Dot plots presenting the normalized expression levels of corresponding markers of each gene expression program of the malignant cells in the STRT dataset. d Scatterplot showing the developmental trajectory of malignant cell identified by different expression programs using monocle2. e Boxplot showing the signaling entropy rate of cells with identified gene expression programs. f Heatmap showing diverse expression patterns of the malignant cells from different expression programs along the pseudotime trajectory. g Scatterplot exhibiting the negative correlation of metabolism- and EMT-related malignant cells. h Scatterplot exhibiting the expression levels of representative marker genes. i Scatterplot exhibiting the information of malignant cells from lymph nodes and primary tumor tissues embedded in the trajectory pathway. j Heatmap showing the on or off activities in the malignant cells of diverse expression programs. k Scatterplot showing the TF expression scores in the developmental trajectory.