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. 2022 Sep 14;8:92. doi: 10.1038/s41421-022-00434-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Scatterplots exhibiting the PCA dimension reduction analysis for gastric, duodenal, jejunal to colorectal malignant cells and DEGs expressed in the PCA plot. b Violin plot exhibiting markers of SBA expressed in gastrointestinal cancers. c, d Heatmap showing gene set scores of hallmark gene sets and metabolism pathways in malignant cells from different gastrointestinal regions. e Enrichment analysis for markers of malignant cells in SBA and CRC. f Heatmap showing the TF activities of GRNs in malignant cells from SBA and CRC.