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. 2022 Sep 14;5:915. doi: 10.1038/s42003-022-03876-x

Fig. 1. Schematic diagram showing types of DRG-lesioned mice created in this study.

Fig. 1

Two major spinal afferent populations innervate the colon and rectum. They arise from the thoracolumbar DRG and the lumbosacral DRG. To study their functions, mice lacking either pathway were created by bilateral removal of the L5-S1 DRG (shown left), or the T13-L1 DRG (right). Unilateral removal of T13-L2 was used to study the uterine horns, allowing contralateral internal controls to be used. CG-SMG Celiac-superior mesenteric ganglia, IMG inferior mesenteric ganglion, LSN lumbar splanchnic nerve, PG pelvic ganglia, PN pelvic nerve, PVG prevertebral ganglion, DRG dorsal root ganglia, SC spinal cord.