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. 2022 Sep 14;5:915. doi: 10.1038/s42003-022-03876-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 10 — a The removal of L5-S1 DRG had no significant effect on the frequency of the colonic motor complex ex vivo (mean intervals: 225 ± 74 vs. 196 ± 41 s, control vs. LS lesion, respectively; P = 0.522, t = 0.680, DF = 6; independent samples 2 tailed t test, N = 4 in each group). Error bars represent mean ± SD, individual markers represent individual animal averages. b, c Representative mechanical recordings from control and LS lesioned mice, respectively. Hexamethonium promptly abolished high amplitude contractions in both examples, confirming their dependence on nicotinic transmission within the enteric nervous system.