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. 2022 May 18;28(18):3929–3939. doi: 10.1158/1078-0432.CCR-21-3304

Figure 1.

Figure 1. Overview of coding and noncoding RNA structures. Left, in vitro transcription (iVT) of messenger RNA (mRNA). mRNA has several conserved features including a 5′ cap structure, two extended untranslated regions (UTRs) at the 5′ and 3′ end of the ORF, and a 3′ poly-A tail. The final iVT product can be mRNA or self-amplifying mRNA. Right, solid-phase synthesis of noncoding and antisense oligonucleotides. Abbreviations: mRNA, messenger RNA; UTR, untranslated region; rNTP, ribonucleoside triphosphates; miRNA, microRNA; siRNA, small interfering RNA; ASO, antisense oligonucleotides, siRNA, small interfering RNA. Adapted from an image created with BioRender.com.

Overview of coding and noncoding RNA structures. Left, in vitro transcription (iVT) of messenger RNA (mRNA). mRNA has several conserved features, including a 5′ cap structure, two extended untranslated regions (UTR) at the 5′ and 3′ end of the ORF, and a 3′ poly-A tail. The final iVT product can be mRNA or self-amplifying mRNA. Right, solid-phase synthesis of noncoding and antisense oligonucleotides. Abbreviations: ASO, antisense oligonucleotides; mRNA, messenger RNA; UTR, untranslated region; rNTP, ribonucleoside triphosphates; miRNA, microRNA; siRNA, small interfering RNA. Adapted from an image created with BioRender.com.